Flow and transport in the placenta

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Title

Flow and transport in the placenta

Group Continuum Mechanics
Supervisor
Description

The placenta provides an interface beween fetal and maternal blood, supplying essential nutrients to the growing fetus.  Within the placenta, fetal blood is confined to a tree-like network of blood vessels that are bathed in a pool of maternal blood.  The placenta's effectiveness as a transporter of oxygen, glucose, and other molecules is critically determined by its complex geometric structure;  this may be compromised in disease, with adverse consequences for fetal growth and development.  This project will build on recent studies of the maternal circulation [1-3], developing analogies with models flow through porous media and exploring new multiscale approximation techniques.  The project offers opportunities for analysis, computation and interaction with experimentalists.

References:

  1. Chernyavsky, IL, Jensen, OE et al. (2010) Placenta 31, 44
  2. Chernyavsky, IL, Leach, L et al.  (2011) Phil Trans Roy Soc A 369, 4162
  3. Chernyavsky, IL, Dryden, IL et al. (2012) IMA J Appl Math 77, 697
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