Estimating whole brain dynamics using spectral clustering

Yi Yu (University of Bristol)

Frank Adams 2,

The estimation of time-varying networks for functional Magnetic Resonance Imaging (fMRI) data sets is of increasing importance and interest.  In this work, we formulate the problem in a high-dimensional time series framework and introduce a data-driven method, namely Network Change Points Detection (NCPD), which detects change points in the network structure of a multivariate time series, with each component of the time series represented by a node in the network.  NCPD is applied to various simulated data and a resting-state fMRI data set. This new methodology also allows us to identify common functional states within and across subjects.  Finally, NCPD promises to offer a deep insight into the large-scale characterisations and dynamics of the brain.  This is joint work with Ivor Cribben (Alberta School of Business).

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