Bistability in Circadian Clock

Dana Alsaleh (University of Manchester)

ATB Frank Adams 1,

In most organisms, the physiology and behaviour are regulated by the circadian rhythms. These rhythms are controlled by a master clock which is called suprachiasmatic nucleus (SCN). In the SCN, it has been shown that there are two categories of neurons, per1 and non-per1 neurons. Per1 neurons express period (per1) gene which plays a key role in the molecular mechanism of the master clock while non-per1 neurons do not express per1 gene.

A previous experiment illustrated that per1 neurons have different behaviour over a day- night cycle from non-per1 neurons. It revealed that during the afternoon per1 neurons are divided into two groups: GA shows low amplitude oscillations (LAOs) while GB is in quiescence state (Q).

In this talk I will focus on modelling the two behaviours of per1 neurons, LAOs and Q, in the afternoon. Before modelling these behaviours I will discuss some general aspects of bifurcation which represent the main base for the work. Then I will present the mathematical model of per1 neurons and some interesting properties about the behavoiur of these neurons in the afternoon.

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