Title
A Short Note on Delay Effects in Cell Proliferation
Authors
Christopher T.H. Baker, Gennadii A. Bocharov, Christopher A.H. Paul & A.A. Romanyukha
Keywords
Parameter estimation, delay differential equations, mathematical modelling
Report No.
266
Date
18th May 1995
Status
File size
66Kb
Abstract
We show that a growth model for cell proliferation that incorporates a time-lag in the cell division phase is more consistent with certain reported data than the classical exponential growth model. Although both models provide estimates of some of the growth characteristics, such as the population-doubling time, the time-lag growth model additionally provides estimates of: (i) the cell-doubling time, (ii) the fraction of the cells that are dividing, (iii) the rate of commitment to cell division and, (iv) the initial distribution of cells in the cell cycle.
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