Quantifying Heterogeneity in Macrophage Phenotype During Tissue Repair and Regeneration

Kimberley Mace (University of Manchester)

Conference Room B, Schuster,

Macrophages play a diverse role during tissue repair and regeneration and are necessary in adult cutaneous healing for effective repair. Recent work from our lab and others has demonstrated that pathological conditions that impair wound healing are associated with dysfunctional macrophages and a skew in subtype composition within the damaged tissue. However, little is known about their heterogeneity at different phases of repair, and how pathological conditions, such as diabetes, affect the sub-type composition. We are utilising imaging to try to better understand this problem and hope to combine this data with quantitative gene expression data to identify important targets for manipulation to improve macrophage function, and ultimately healing.

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